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Clinical History:
59 year-old female, status post orthotopic heart
transplant one year ago secondary to adriamycin induced
cardiomyopathy. Her previous biopsies were with no signs of
rejection.
Histology: Images
for suboptimal biopsy (Figure A) and normal myocardial
tissue from a different heart allograft (Figure B) are
presented as references. Patient's sections with H&E
staining (Figures C & E) show perivascular mononuclear
cell infiltration with a single focus of associated
myocyte damage consistent with mild acute cellular
rejection, ISHLT 2004 Grade 1R (ISHLT 1990 Grade 1A). Trichrome staining
from consecutive sections from C & E (Figures D & F)
reveal mild interstitial edema. |
